ISA is about the 5th computing era : The Distribution one.
When the things are done in many computing units, of many kinds, in many places, available to anyone. When the centralization is no more possible.
cloud computing
The world, the universe is not centralized. They don’t have center. Any attempt to ignore this fact in an ideal architecture will fail.
Distributed computing and storage have to be at the heart of ISA in order to adhere to the reality.
An other aspect of distribution paradigm, implies that the data and treatments are scaling horizontally. Taking advantage of all 4 dimensions of our universe.